The word(s) "sign" appears 461 time(s) in 421 verse(s) in Quran in Abdullah Yusuf Ali translation.

(241) "But those who strive against Our signs, to frustrate them,- they will be Companions of the Fire."

(242) Never did We send a messenger or a prophet before thee, but, when he framed a desire, Satan threw some (vanity) into his desire: but Allah will cancel anything (vain) that Satan throws in, and Allah will confirm (and establish) His signs: for Allah is full of Knowledge and Wisdom:

(243) And for those who reject Faith and deny our signs, there will be a humiliating Punishment.

(244) When Our Clear signs are rehearsed to them, thou wilt notice a denial on the faces of the Unbelievers! they nearly attack with violence those who rehearse Our signs to them. Say, "Shall I tell you of something (far) worse than these signs? It is the Fire (of Hell)! Allah has promised it to the Unbelievers! and evil is that destination!"

(245) Verily in this there are signs (for men to understand); (thus) do We try (men).

(246) Then We sent Moses and his brother Aaron, with Our signs and authority manifest,

(247) And We made the son of Mary and his mother as a sign: We gave them both shelter on high ground, affording rest and security and furnished with springs.

(248) Those who believe in the signs of their Lord;

(249) "My signs used to be rehearsed to you, but ye used to turn back on your heels-

(250) "Were not My signs rehearsed to you, and ye did but treat them as falsehood?"